3rd semester physical Pharmaceutics Notes

Welcome to Bright Medico, your ultimate destination for 3rd semester Physical Pharmaceutics notes. We understand the significance of mastering the principles and techniques of Physical Pharmaceutics in the pharmaceutical industry, and our goal is to provide you with comprehensive and concise study materials to aid your learning journey.

Our 3rd semester Physical Pharmaceutics notes not only provide theoretical explanations but also offer practical insights into real-world applications. You’ll find examples, case studies, and illustrations that bridge the gap between theory and practice, helping you develop a deeper understanding of the subject matter.


Solubility of drugs:
Solubility expressions, mechanisms of solute solvent interactions, ideal solubility parameters, solvation & association, quantitative approach to the factors influencing solubility of drugs, diffusion principles in biological systems. Solubility of gas in liquids, solubility of liquids in liquids, (Binary solutions, ideal solutions) Raoult’s law, real solutions. Partiallymiscible liquids, Critical solution temperature and applications. Distribution law, its limitations and applications


States of Matter and properties of matter:

State of matter, changes in the state of matter, latent heats, vapour pressure, sublimation critical point, eutectic mixtures, gases, aerosols – inhalers, relative humidity, liquid complexes, liquid crystals, glassy states, solidcrystalline, amorphous & polymorphism.

Physicochemical properties of drug molecules:

Refractive index, optical rotation, dielectric constant, dipole moment, dissociation constant, determinations and applications


Surface and interfacial phenomenon:

Liquid interface, surface & interfacial tensions, surface free energy, measurement of surface & interfacial tensions, spreading coefficient, adsorption at liquid interfaces, surface active agents, HLB Scale, solubilisation, detergency, adsorption at solid interface.


Complexation and protein binding:

Introduction, Classification of Complexation, Applications, methods of analysis, protein binding, Complexation and drug action, crystalline structures of complexes and thermodynamic treatment of stability constants.


pH, buffers and Isotonic solutions:

Sorensen’s pH scale, pH determination (electrometric and calorimetric), applications of buffers, buffer equation, buffer capacity, buffers in pharmaceutical and biological systems, buffered isotonic solutions.

We understand that every student has unique learning preferences, which is why we provide a range of formats for our notes. You can access our materials in digital formats for easy online reading or download and print them for offline studying. The choice is yours!

Thank you for choosing Bright Medico as your learning companion for 3rd semester Physical Pharmaceutics. We are committed to providing you with top-notch educational resources that will empower you to excel in your studies. Get ready to expand your understanding, enhance your skills, and embark on a successful academic journey. Together, let’s achieve greatness in the field of Physical Pharmaceutics!

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