4th Semester Medicinal Chemistry Notes

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Our website is specifically designed to provide you with detailed notes on various aspects of 4th Semester Medicinal Chemistry Notes. From drug design and synthesis to the principles of pharmacology, our curated collection of notes will help you grasp the fundamental concepts and applications of this crucial discipline.

Unit-1

  • Introduction to Medicinal Chemistry
  • History and development of medicinal chemistry
  • Physicochemical properties in relation to biological action
  • Ionization, Solubility, Partition Coefficient, Hydrogen bonding, Protein binding, Chelation, Bioisosterism, Optical and Geometrical isomerism
  • Drug metabolism
  • Drug metabolism principles- Phase I and Phase II
  • Factors affecting drug metabolism including stereochemical aspects

Unit-2

  • Drugs Acting on Autonomic Nervous System
  • Adrenergic Neurotransmitters:
  • Biosynthesis and catabolism of catecholamine.
  • Adrenergic receptors (Alpha & Beta) and their distribution.
  • Sympathomimetic agents: SAR of Sympathomimetic agents
  • Direct acting: Nor-epinephrine, Epinephrine, Phenylephrine\*, Dopamine, Methyldopa, Clonidine, Dobutamine, Isoproterenol, Terbutaline, Salbutamol\*, Bitolterol, Naphazoline, Oxymetazoline and Xylometazoline.
  • Indirect-acting agents: Hydroxyamphetamine, Pseudoephedrine, Propylhexedrine.
  • Agents with mixed mechanism: Ephedrine, Metaraminol

Unit-3

  • Cholinergic neurotransmitters:
  • Biosynthesis and catabolism of acetylcholine.
  • Cholinergic receptors (Muscarinic & Nicotinic) and their distribution.
  • Parasympathomimetic agents: SAR of Parasympathomimetic agents
  • Direct acting agents:
  • Acetylcholine, Carbachol\*, Bethanechol, Methacholine, Pilocarpine.
  • Indirect acting/ Cholinesterase inhibitors (Reversible & Irreversible):
  • Physostigmine, Neostigmine\*, Pyridostigmine, Edrophonium chloride, Tacrine hydrochloride, Ambenonium chloride, Isofluorphate, Echothiophate iodide, Parathion, Malathion.
  • Cholinesterase reactivator:

Pralidoxime chloride.

  • Cholinergic Blocking agents: SAR of cholinolytic agents
  • Synthetic cholinergic blocking agents:
  • Atropine sulphate, Hyoscyamine sulphate, Scopolamine hydrobromide, Homatropine hydrobromide, Ipratropium bromide*.
  • Synthetic cholinergic blocking agents:
  • Tropicamide, Cyclopentolate hydrochloride, Clidinium bromide, Dicyclomine hydrochloride\*, Glycopyrrolate, Methantheline bromide, Propantheline bromide, Benztropine mesylate, Orphenadrine citrate, Biperidine hydrochloride, Procyclidine hydrochloride\*, Tridihexethyl chloride, Isopropamide iodide, Ethopropazine hydrochloride.

Unit-4

  • Drugs acting on Central Nervous System
  • Sedatives and Hypnotics

Benzodiazepines:

  • SAR of Benzodiazepines, Chlordiazepoxide, Diazepam\*, Oxazepam, Chlorazepate, Lorazepam, Alprazolam, Zolpidem

Barbiturates:

  • SAR of barbiturates, Barbital\*, Phenobarbital, Mephobarbital, Amobarbital, Butabarbital, Pentobarbital, Secobarbital

Miscellaneous:

  • Amides & imides: Glutethmide.
  • Alcohol & their carbamate derivatives: Meprobomate, Ethchlorvynol.
  • Aldehyde & their derivatives: Triclofos sodium, Paraldehyde.

Antipsychotics

  • Phenothiazines: SAR of Phenothiazeines – Promazine hydrochloride, Chlorpromazine hydrochloride\*,
  • Triflupromazine, Thioridazine hydrochloride, Piperacetazine hydrochloride,
  • Prochlorperazine maleate, Trifluoperazine hydrochloride.
  • Ring Analogues of Phenothiazeines:
  • Chlorprothixene, Thiothixene, Loxapine succinate, Clozapine.
  • Fluro buterophenones: Haloperidol, Droperidol, Risperidone.
  • Beta amino ketones: Molindone hydrochloride.
  • Benzamides: Sulpieride.

. Anticonvulsants:

  • SAR of Anticonvulsants, mechanism of anticonvulsant action
  • Barbiturates: Phenobarbitone, Methabarbital.
  • Hydantoins: Phenytoin\*, Mephenytoin, Ethotoin
  • Oxazolidine diones: Trimethadione, Paramethadione
  • Succinimides: Phensuximide, Methsuximide, Ethosuximide*
  • Urea and monoacylureas: Phenacemide, Carbamazepine*
  • Benzodiazepines: Clonazepam
  • Miscellaneous: Primidone, Valproic acid, Gabapentin, Felbamate

Unit-5

  • Drugs Acting on Central Nervous System
  • General anesthetics:
  • Inhalation anesthetics: Halothane\*, Methoxyflurane, Enflurane, Sevoflurane, Isoflurane, Desflurane.
  • Ultra short-acting barbiturates: Methohexital sodium\*, Thiamylal sodium, Thiopental sodium.
  • Dissociative anesthetics: Ketamine hydrochloride.\*
  • Narcotic and non-narcotic analgesics
  • Morphine and related drugs: SAR of Morphine analogues, Morphine sulphate, Codeine, Meperidine hydrochloride, Anilerdine hydrochloride, Diphenoxylate hydrochloride, Loperamide hydrochloride, Fentanyl citrate\*, Methadone hydrochloride\*, Propoxyphene hydrochloride, Pentazocine, Levorphanol tartarate.
  • Narcotic antagonists: Nalorphine hydrochloride, Levallorphan tartarate, Naloxone hydrochloride.
  • Anti-inflammatory agents: Sodium salicylate, Aspirin, Mefenamic acid\*, Meclofenamate, Indomethacin, Sulindac, Tolmetin, Zomepriac, Diclofenac, Ketorolac, Ibuprofen\*, Naproxen, Piroxicam, Phenacetin, Acetaminophen, Antipyrine, Phenylbutazone.

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