4th semester Pharmaceutical Organic Chemistry Notes

Welcome to Bright Medico, your trusted source for 4th semester Pharmaceutical Organic Chemistry notes. We understand the significance of this subject in the pharmaceutical industry, and our goal is to provide you with comprehensive and high-quality study materials.

Our meticulously crafted 4th semester Pharmaceutical Organic Chemistry Notes. cover a wide range of topics, including advanced organic reactions, drug design and development, stereochemistry, and more. Each topic is presented in a clear and concise manner, making it easier for you to grasp complex concepts.

Unit-1

Stereo isomerism

  • Optical isomerism – Optical activity, enantiomerism, diastereoisomerism, meso compounds
  • Elements of symmetry, chiral and achiral molecules
  • DL system of nomenclature of optical isomers, sequence rules, RS system of nomenclature of optical isomers
  • Reactions of chiral molecules
  • Racemic modification and resolution of racemic mixture. Asymmetric synthesis: partial and absolute

Unit-2

Geometrical isomerism

  • Nomenclature of geometrical isomers (Cis Trans, EZ, Syn Anti systems)
  • Methods of determination of configuration of geometrical isomers.
  • Conformational isomerism in Ethane, n-Butane and Cyclohexane. Stereo isomerism in biphenyl compounds (Atropisomerism) and conditions for optical activity.
  • Stereospecific and stereoselective reactions

Unit-3

Heterocyclic compounds:

  • Nomenclature and classification
  • Synthesis, reactions and medicinal uses of following compounds/derivatives
  • Pyrrole, Furan, and Thiophene
  • Relative aromaticity and reactivity of Pyrrole, Furan and Thiophene

Unit-4

  • Synthesis, reactions and medicinal uses of following compounds/derivatives
  • Pyrazole, Imidazole, Oxazole and Thiazole.
  • Pyridine, Quinoline, Isoquinoline, Acridine and Indole. Basicity of pyridine
  • Synthesis and medicinal uses of Pyrimidine, Purine, azepines, and their derivatives.

Unit-5

Reactions of synthetic importance

  • Metal hydride reduction (NaBH4 and LiAlH4), Clemmensen reduction, Birch reduction, Wolff Kishner reduction.
  • Oppenauer-oxidation and Dakin reaction.
  • Beckmann rearrangement and Schmidt rearrangement.
  • Claisen-Schmidt condensation

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