“Welcome to the fascinating world of 5th semester Medicinal Chemistry! As we delve deeper into this subject, get ready to explore the intricate relationship between chemistry and medicine. From understanding the molecular structures of drugs to unraveling their mechanisms of action, this semester’s study material will open doors to a realm where science meets healing. Let’s embark on this enlightening journey together!”

5th semester Medicinal Chemistry

Unit-1

Antihistaminic agents

  • Histamine, receptors and their distribution in the human body
  • H1-antagonists: Diphenhydramine hydrochloride\*, Dimenhydrinate, Doxylamines cuccinate, Clemastine fumarate, Diphenylphyraline hydrochloride, Tripelenamine hydrochloride, Chlorcyclizine hydrochloride, Meclizine hydrochloride, Buclizine hydrochloride, Chlorpheniramine maleate, Triprolidine hydrochloride\*, Phenidamine tartarate, Promethazine hydrochloride\*, Trimeprazine tartrate, Cyproheptadine hydrochloride, Azatidine maleate, Astemizole, Loratadine, Cetirizine, Levocetrazine Cromolyn sodium
  • H2-antagonists: Cimetidine\*, Famotidine, Ranitidin.
  • Gastric Proton pump inhibitors: Omeprazole, Lansoprazole, Rabeprazole, Pantoprazole

Anti-neoplastic agents

  • Alkylating agents: Meclorethamine\*, Cyclophosphamide, Melphalan, Chlorambucil, Busulfan, Thiotepa
  • Antimetabolites: Mercaptopurine\*, Thioguanine, Fluorouracil, Floxuridine, Cytarabine, Methotrexate\*, Azathioprine
  • Antibiotics: Dactinomycin, Daunorubicin, Doxorubicin, Bleomycin
  • Plant products: Etoposide, Vinblastin sulphate, Vincristin sulphate
  • Miscellaneous: Cisplatin, Mitotane

Unit-2

Anti-anginal

  • Vasodilators: Amyl nitrite, Nitroglycerin\*, Pentaerythritol tetranitrate, Isosorbide dinitrite\*, Dipyridamole.
  • Calcium channel blockers: Verapamil, Bepridil hydrochloride, Diltiazem hydrochloride, Nifedipine, Amlodipine, Felodipine, Nicardipine, Nimodipine.

Diuretics

  • Carbonic anhydrase inhibitors: Acetazolamide\*, Methazolamide, Dichlorphenamide.
  • Thiazides: Chlorthiazide\*, Hydrochlorothiazide, Hydroflumethiazide, Cyclothiazide,
  • Loop diuretics: Furosemide\*, Bumetanide, Ethacrynic acid.
  • Potassium sparing Diuretics: Spironolactone, Triamterene, Amiloride.
  • Osmotic Diuretics: Mannitol

Anti-hypertensive Agents

  • Timolol, Captopril, Lisinopril, Enalapril, Benazepril hydrochloride, Quinapril hydrochloride, Methyldopate hydrochloride,* Clonidine hydrochloride, Guanethidine monosulphate, Guanabenz acetate, Sodium nitroprusside, Diazoxide, Minoxidil, Reserpine, Hydralazine hydrochloride.

Unit-3

  • Anti-arrhythmic Drugs: Quinidine sulphate, Procainamide hydrochloride, Disopyramide phosphate\*, Phenytoin sodium, Lidocaine hydrochloride, Tocainide hydrochloride, Mexiletine hydrochloride, Lorcainide hydrochloride, Amiodarone, Sotalol.
  • Anti-hyperlipidemic agents: Clofibrate, Lovastatin, Cholesteramine and Cholestipol
  • Coagulant & Anticoagulants: Menadione, Acetomenadione, Warfarin\*, Anisindione, clopidogrel
  • Drugs used in Congestive Heart Failure: Digoxin, Digitoxin, Nesiritide, Bosentan, Tezosentan.

Unit-4

Drugs Acting on Endocrine system

  • Nomenclature, Stereochemistry, and metabolism of steroids
  • Sex hormones: Testosterone, Nandralone, Progestrones, Oestriol, Oestradiol, Oestrione, Diethyl stilbestrol.
  • Drugs for erectile dysfunction: Sildenafil, Tadalafil.
  • Oral contraceptives: Mifepristone, Norgestril, Levonorgestrol
  • Corticosteroids: Cortisone, Hydrocortisone, Prednisolone, Betamethasone, Dexamethasone
  • Thyroid and antithyroid drugs: L-Thyroxine, L-Thyronine, Propylthiouracil, Methimazol

Unit-5

Antidiabetic agents:

  • Insulin and its preparations
  • Sulfonyl ureas: Tolbutamide\*, Chlorpropamide, Glipizide, Glimepiride.
  • Biguanides: Metformin.
  • Thiazolidinediones: Pioglitazone, Rosiglitazone
  • Meglitinides: Repaglinide, Nateglinide.
  • Glucosidase inhibitors:Acrabose, Voglibose.
  • Local Anesthetics: SAR of Local anesthetics
  • Benzoic Acid derivatives: Cocaine, Hexylcaine, Meprylcaine, Cyclomethycaine, Piperocaine.
  • Lidocaine/Anilide derivatives: Lignocaine, Mepivacaine, Prilocaine, Etidocaine.
  • Miscellaneous: Phenacaine, Diperodon, Dibucaine.

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