6th Semester Biopharmaceutics  | bright medico notes | Biopharmaceutics | bpharma notes

Welcome to the 6th Semester Biopharmaceutics page of Bright Medico! Here, you will find a comprehensive guide to the study of biopharmaceutics, which is a crucial aspect of pharmacy and drug development. From drug absorption and distribution to pharmacokinetics and drug delivery systems, this page covers all the essential topics that you need to know to excel in this field. Whether you are a student or a professional, we hope that this page will be a valuable resource for you. So, let’s dive in!

Unit-1

Introduction Of Biopharmaceutics

  • Absorption; Mechanisms of drug absorption through GIT, factors influencing drug absorption through GIT, absorption of the drug from Non per oral extra-vascular routes,
  • Distribution Tissue permeability of drugs, binding of drugs, apparent, volume of drug distribution, plasma and tissue protein binding of drugs, factors affecting protein-drug binding. Kinetics of protein binding, Clinical significance of protein binding of drugs

Unit-2

Elimination: Drug metabolism and basic understanding of the metabolic pathways renal experience excretion of drugs, Factors affecting the excretion of drugs, renal and non-renal clearance with the routes of drug excretion.

• Bioavailability and Bioequivalence: Objectives and Definitions of Bioavailability, Absolute and relative bioavailability, Measurements of bioavailability, in-vitro drug dissolution models, in-vitro-in-vivo correlations, Methods to increase the dissolution rates and bioavailability of poorly soluble drugs, Bioequivalence studies

Unit-3

Pharmacokinetics: Pharmacokinetics definitions and introduction, Compartment models, Non-compartment models, physiological models, One compartment open model. (i) Intravenous Injection (Bolus), (ii) Intravenous infusion, and (iii) Extra-vascular administration, Pharmacokinetics parameters- KE, t1/2, Vd, AUC, Ka, Clt, and CLR – Definitions methods of elimination, Understanding of their significance and applications

Unit-4

Multi-compartment models: Two-compartment open model, IV bolus kinetics of the multiple doses, Steady-state drug levels, Calculation of the loading maintenance doses and their significance.

Unit-5

Nonlinear Pharmacokinetics: Introduction, Factors causing non-linearity, Michaelis-Menton method of estimating parameters, Explanation with an example of the drugs

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