Welcome to the captivating realm of the 6th semester in B.Pharm, where we embark on a journey through the fascinating world of Pharmaceutical Biotechnology. This semester delves into the cutting-edge intersection of pharmaceutical science and biotechnology, offering a deep dive into the revolutionary advances shaping the future of medicine. As we explore the intricate synergy between biology, technology, and pharmaceuticals, get ready to unravel the potential of biotechnology to transform healthcare on a global scale

6th semester Pharmaceutical Biotechnology | bright medico notes
| b.pharma notes

Unit -1

  • A brief introduction to Biotechnology with reference to Pharmaceutical Sciences.
  • Enzyme Biotechnology- Methods of enzyme immobilization and applications.
  • Biosensors- Working and applications of biosensors in Pharmaceutical Industries.
  • Brief introduction to Protein Engineering.
  • Use of microbes in industry
  • Basic principles of genetic engineering

Unit-2

  •  Study of cloning vectors, restriction endonucleases and DNA ligase.
  • 2. Recombinant DNA technology
  • 3. Application of r DNA technology and genetic engineering in the production of:
  • Interferon
  • Vaccines- hepatitis- B
  • Hormones-Insulin.

Unit -3

  • types of immunity- humoral immunity, cellular immunity
  • Structure of Immunoglobulins
  • Structure and Function of MHC
  • Hypersensitivity reactions, Immune stimulation and Immune suppressions.
  • General method of the preparation of bacterial vaccines, toxoids, viral vaccine, antitoxins, serum-immune blood derivatives and other products relative to immunity.
  • Storage conditions and stability of official vaccines
  • Hybridoma technology- Production, Purification and Applications
  • Blood products and Plasma Substituties.

Unit-4

  • Immunoblotting techniques- ELISA, Western blotting, Southern blotting.
  • Genetic Organization of Eukaryotes and Prokaryotes
  • Microbial genetics include transformation, transduction, conjugation, plasmids, and transposons.
  • Introduction to Microbial biotransformation and applications.
  • Mutation: Types of mutation/mutants.

Unit-5

  • Fermentation methods and general requirements, study of media, equipment, sterilization methods, aeration process, stirring.
  • Large-scale production fermenter design and its various controls.
  • Study of the production of – penicillins, citric acid, Vitamin B12, Glutamic acid, Griseofulvin,
  • Blood Products: Collection, Processing and Storage of whole human blood, dried human plasma, plasma Substitutes

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